Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research (Applied Bioinformatics and Biostatistics in Cancer Research)


  Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research (Applied Bioinformatics and Biostatistics in Cancer Research)  Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly... купить, скачать, интернет магазин Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly......


Jets From Young Stars III: Numerical MHD and Instabilities (Lecture Notes in Physics)


  Jets From Young Stars III: Numerical MHD and Instabilities (Lecture Notes in Physics)  This volume contains the lecture notes of the Third JETSET School on Jets from Young Stars focussing on Numerical MHD and Instabilities. The introductory lectures presented here cover the basic concepts of the numerical methods for the integration of hydrodynamic and magnetohydrodynamic equations and of the applications of these methods to the treatment of the instabilities relevant for the physics of stellar jets. The first part of the book contains an introduction to the finite difference and finite volume methods for computing the solutions of hyperbolic partial differential equations and a discussion of approximate Riemann solvers for both hydrodynamic and magnetohydrodynamic problems. The second part is devoted to the discussion of some of the main instability processes that may take place in stellar jets, namely: the Kelvin-Helmholtz, the radiative shock, the pressure driven and the thermal instabilities. Graduate students and young scientists will benefit from this book by... купить, скачать, интернет магазин This volume contains the lecture notes of the Third JETSET School on Jets from Young Stars focussing on Numerical MHD and Instabilities. The introductory lectures presented here cover the basic concepts of the numerical methods for the integration of hydrodynamic and magnetohydrodynamic equations and of the applications of these methods to the treatment of the instabilities relevant for the physics of stellar jets. The first part of the book contains an introduction to the finite difference and finite volume methods for computing the solutions of hyperbolic partial differential equations and a discussion of approximate Riemann solvers for both hydrodynamic and magnetohydrodynamic problems. The second part is devoted to the discussion of some of the main instability processes that may take place in stellar jets, namely: the Kelvin-Helmholtz, the radiative shock, the pressure driven and the thermal instabilities. Graduate students and young scientists will benefit from this book by......

Can't Live Without It: The Story of Hemoglobin in Sickness and in Health

Loren F. Hazelwood


  Can't Live Without It: The Story of Hemoglobin in Sickness and in Health  Loren F. Hazelwood  Why is blood red? Because it contains Hemoglobin - the most important molecule in the human body. In health - the average person has 4 lbs. of hemoglobin and manufactures seven billion molecules of hemoglobin every second. It carries oxygen from the lungs to the cells and helps the body remove waste carbon dioxide. In sickness - an estimated one billion people around the world have some disorder related to hemoglobin: sickle-cell anemia, pernicious anemias, iron-deficiency anemia, porphyrias, hemoglobin E disease, alpha-thalassemia, beta- thalassemia, and G6PD deficiency. One type of hemoglobin can be used to monitor diabetes. This basic introduction to hemoglobin includes information on the reelection of Richard Nixon, the madness of King George III, werewolves, lead poisoning, legends about Pythagoras, genetics and genetic screening, diabetes, respiration, the production of red cells, and translation of the DNA code. Hemoglobin is a fascination molecule that touches our lives,... купить, скачать, интернет магазин Why is blood red? Because it contains Hemoglobin - the most important molecule in the human body. In health - the average person has 4 lbs. of hemoglobin and manufactures seven billion molecules of hemoglobin every second. It carries oxygen from the lungs to the cells and helps the body remove waste carbon dioxide. In sickness - an estimated one billion people around the world have some disorder related to hemoglobin: sickle-cell anemia, pernicious anemias, iron-deficiency anemia, porphyrias, hemoglobin E disease, alpha-thalassemia, beta- thalassemia, and G6PD deficiency. One type of hemoglobin can be used to monitor diabetes. This basic introduction to hemoglobin includes information on the reelection of Richard Nixon, the madness of King George III, werewolves, lead poisoning, legends about Pythagoras, genetics and genetic screening, diabetes, respiration, the production of red cells, and translation of the DNA code. Hemoglobin is a fascination molecule that touches our lives,......

Surgically Shaping Children: Technology, Ethics, and the Pursuit of Normality


  Surgically Shaping Children: Technology, Ethics, and the Pursuit of Normality  At a time when medical technologies make it ever easier to enhance our minds and bodies, a debate has arisen about whether such efforts promote a process of At a time when medical technologies make it ever easier to enhance our minds and bodies, a debate has arisen about whether such efforts promote a process of "normalization," which makes it ever harder to tolerate the natural anatomical differences among us. The debate becomes especially complicated when it addresses the surgical alteration, or "shaping," of children. This volume explores the ethical and social issues raised by the recent proliferation of surgeries designed to make children born with physical differences look more normal.Using three cases -- surgeries to eliminate craniofacial abnormalities such as cleft lip and palate, surgeries to correct ambiguous genitalia, and surgeries to lengthen the limbs of children born with dwarfism -- the contributors consider the tensions parents experience when making such life-altering decisions on behalf of or with their children.The essays in this volume offer in-depth examinations of the significance and limits of surgical alteration......

Calculation Of Columns: A Practical Application Of The Theory

Theodor Nielsen


  Calculation Of Columns: A Practical Application Of The Theory  Theodor Nielsen  Calculation Of Columns : A Practical Application Of The Theory, BY THEODOR NIELSEN. EXPERIMENTS and calculation show that the centre line of a column will, if deflected, assume a wave line, and the free length will be cotisidered as the distance between two consecutive points of contraflexure, this being the length of a column with ideal pin ends. The first step in all column calculations is to deduce the free length from the actual length, and it is also the weak point of such caIculations, as the Bee length depends upon the nature of the fixing of the ends which may even cause some eccentricity of the loading. In case where any doubt exists it is better to assume a greater free length, say full length, of the column even if the ends are held. As a guide the following will prove useful, but much depends upon individual judgment. Both ends free the free length G L is purely ideal, but very often allowed. купить, скачать, интернет магазин Calculation Of Columns : A Practical Application Of The Theory, BY THEODOR NIELSEN. EXPERIMENTS and calculation show that the centre line of a column will, if deflected, assume a wave line, and the free length will be cotisidered as the distance between two consecutive points of contraflexure, this being the length of a column with ideal pin ends. The first step in all column calculations is to deduce the free length from the actual length, and it is also the weak point of such caIculations, as the Bee length depends upon the nature of the fixing of the ends which may even cause some eccentricity of the loading. In case where any doubt exists it is better to assume a greater free length, say full length, of the column even if the ends are held. As a guide the following will prove useful, but much depends upon individual judgment. Both ends free the free length G L is purely ideal, but very often allowed....

The History of Medicine: A Very Short Introduction (Very Short Introductions)

William Bynum


  The History of Medicine: A Very Short Introduction (Very Short Introductions)  William Bynum  Against the backdrop of unprecedented concern for the future of health care, this Very Short Introduction surveys the history of medicine from classical times, through the scholastic medieval tradition and the Enlightenment to the present day. Taking a thematic rather than strictly chronological approach, W.F. Bynum, explores the key turning points in the history of Western medicine-such as the first surgical procedures, the advent of hospitals, the introduction of anesthesia, X-Rays, vaccinations, and many other innovations, as well as the rise of experimental medicine. The book also explores Western medicine's encounters with Chinese and Indian medicine, as well as nontraditional treatments such as homeopathy, chiropractic, and other alternative medicines. Covering a vast amount of information, this Very Short Introduction sheds new light on medicine's past, while at the same time engaging with contemporary issues, discoveries, and controversies, such as the spiraling costs of... купить, скачать, интернет магазин Against the backdrop of unprecedented concern for the future of health care, this Very Short Introduction surveys the history of medicine from classical times, through the scholastic medieval tradition and the Enlightenment to the present day. Taking a thematic rather than strictly chronological approach, W.F. Bynum, explores the key turning points in the history of Western medicine-such as the first surgical procedures, the advent of hospitals, the introduction of anesthesia, X-Rays, vaccinations, and many other innovations, as well as the rise of experimental medicine. The book also explores Western medicine's encounters with Chinese and Indian medicine, as well as nontraditional treatments such as homeopathy, chiropractic, and other alternative medicines. Covering a vast amount of information, this Very Short Introduction sheds new light on medicine's past, while at the same time engaging with contemporary issues, discoveries, and controversies, such as the spiraling costs of......

The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange

David Baronov


  The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange  David Baronov  Beginning with the colonial era, Western biomedicine has radically transformed African medical beliefs and practices. Conversely, in using Western biomedicine, Africans have also transformed it. The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange contends that contemporary African medical systems—no less “biomedical” than Western medicine—in fact greatly enrich and expand the notion of biomedicine, reframing it as a global cultural form deployed across global networks of cultural exchange. The book analyzes biomedicine as a complex and dynamic sociocultural form, the conceptual premises of which make it necessarily subject to ongoing change and development as it travels the globe. David Baronov captures the complexities of this cultural exchange by using world-systems analysis in a way that places global cultural processes on equal footing with political and economic processes. In doing so, he both allows the story of Africa’s transformation of... купить, скачать, интернет магазин Beginning with the colonial era, Western biomedicine has radically transformed African medical beliefs and practices. Conversely, in using Western biomedicine, Africans have also transformed it. The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange contends that contemporary African medical systems—no less “biomedical” than Western medicine—in fact greatly enrich and expand the notion of biomedicine, reframing it as a global cultural form deployed across global networks of cultural exchange. The book analyzes biomedicine as a complex and dynamic sociocultural form, the conceptual premises of which make it necessarily subject to ongoing change and development as it travels the globe. David Baronov captures the complexities of this cultural exchange by using world-systems analysis in a way that places global cultural processes on equal footing with political and economic processes. In doing so, he both allows the story of Africa’s transformation of......

An Introduction to Mathematics for Engineers Mechanics

Stephen Lee


  An Introduction to Mathematics for Engineers Mechanics  Stephen Lee  This new introductory mechanics textbook is written for engineering students within further and higher education who are looking to bridge the gap between A-Level and university or college. It introduces key concepts in a clear and straightforward manner, with reference to real-world applications and thoroughly explains each line of mathematical development. Together with instructive diagrams, case studies, and many questions to work through, this text will ensure a thorough understanding of the fundamentals of mechanics. An enclosed CD-ROM also contains This new introductory mechanics textbook is written for engineering students within further and higher education who are looking to bridge the gap between A-Level and university or college. It introduces key concepts in a clear and straightforward manner, with reference to real-world applications and thoroughly explains each line of mathematical development. Together with instructive diagrams, case studies, and many questions to work through, this text will ensure a thorough understanding of the fundamentals of mechanics. An enclosed CD-ROM also contains "Personal Tutor" electronic step-by-step worked examples, with voice-over commentary, which take the student through sample problems and solutions....

Foundations of New World Cultural Astronomy: A Reader With Commentary


  Foundations of New World Cultural Astronomy: A Reader With Commentary  Gazing into the black skies from the Anasazi observatory at Chimney Rock or the Castillo Pyramid in the Maya ruins of Chichen Itza, a modern visitor might wonder what ancient stargazers looked for in the skies and what they saw. Once considered unresearchable, these questions now drive cultural astronomers who draw on written and unwritten records and a constellation of disciplines to reveal the wonders of ancient and contemporary astronomies. Cultural astronomy, first called archaeoastronomy, has evolved at ferocious speed since its genesis in the 1960s, with seminal essays and powerful rebuttals published in far-flung, specialized journals. Until now, only the most closely involved scholars could follow the intellectual fireworks. In Foundations of New World Cultural Astronomy, Anthony Aveni, one of cultural astronomy's founders and top scholars, offers a selection of the essays that built the field, from foundational works to contemporary scholarship. Including four decades of... купить, скачать, интернет магазин Gazing into the black skies from the Anasazi observatory at Chimney Rock or the Castillo Pyramid in the Maya ruins of Chichen Itza, a modern visitor might wonder what ancient stargazers looked for in the skies and what they saw. Once considered unresearchable, these questions now drive cultural astronomers who draw on written and unwritten records and a constellation of disciplines to reveal the wonders of ancient and contemporary astronomies. Cultural astronomy, first called archaeoastronomy, has evolved at ferocious speed since its genesis in the 1960s, with seminal essays and powerful rebuttals published in far-flung, specialized journals. Until now, only the most closely involved scholars could follow the intellectual fireworks. In Foundations of New World Cultural Astronomy, Anthony Aveni, one of cultural astronomy's founders and top scholars, offers a selection of the essays that built the field, from foundational works to contemporary scholarship. Including four decades of......

Entropy and the Time Evolution of Macroscopic Systems (International Series of Monographs on Physics)

Jr., Walter T. Grandy


  Entropy and the Time Evolution of Macroscopic Systems (International Series of Monographs on Physics)  Jr., Walter T. Grandy  This book is based on the premise that the entropy concept, a fundamental element of probability theory as logic, governs all of thermal physics, both equilibrium and nonequilibrium. The variational algorithm of J. Willard Gibbs, dating from the 19th Century and extended considerably over the following 100 years, is shown to be the governing feature over the entire range of thermal phenomena, such that only the nature of the macroscopic constraints changes. Beginning with a short history of the development of the entropy concept by Rudolph Clausius and his predecessors, along with the formalization of classical thermodynamics by Gibbs, the first part of the book describes the quest to uncover the meaning of thermodynamic entropy, which leads to its relationship with probability and information as first envisioned by Ludwig Boltzmann. Recognition of entropy first of all as a fundamental element of probability theory in mid-twentieth Century led to deep insights into both statistical... купить, скачать, интернет магазин This book is based on the premise that the entropy concept, a fundamental element of probability theory as logic, governs all of thermal physics, both equilibrium and nonequilibrium. The variational algorithm of J. Willard Gibbs, dating from the 19th Century and extended considerably over the following 100 years, is shown to be the governing feature over the entire range of thermal phenomena, such that only the nature of the macroscopic constraints changes. Beginning with a short history of the development of the entropy concept by Rudolph Clausius and his predecessors, along with the formalization of classical thermodynamics by Gibbs, the first part of the book describes the quest to uncover the meaning of thermodynamic entropy, which leads to its relationship with probability and information as first envisioned by Ludwig Boltzmann. Recognition of entropy first of all as a fundamental element of probability theory in mid-twentieth Century led to deep insights into both statistical......

Science, Religion, and the Future

Charles E. Raven


  Science, Religion, and the Future  Charles E. Raven  A course of eight lectures delivered at Cambridge in 1943. In his introduction Dr Raven suggests that science and religion, as the most formative influence in the educational and the intellectual life of the world, share responsibility for the outbreak of worldwide war. купить, скачать, интернет магазин A course of eight lectures delivered at Cambridge in 1943. In his introduction Dr Raven suggests that science and religion, as the most formative influence in the educational and the intellectual life of the world, share responsibility for the outbreak of worldwide war....

Nanostructure Design: Methods and Protocols (Methods in Molecular Biology)


  Nanostructure Design: Methods and Protocols (Methods in Molecular Biology)  As one of the fastest growing fields of research in the 21st century, nanotechnology is sure to have an enormous impact on many aspects of our lives. Nanostructure Design: Methods and Protocols serves as a major reference for theoretical and experimental considerations in the design of biological and bio-inspired building blocks, the physical characterization of the formed structures, and the development of their technical applications. The chapters contributed by leading experts are divided into two sections, the first of which covers experimental aspects of nanostructure design and the second delves into computational methods. As a volume of the highly successful Methods in Molecular Biology™ series, this collection pulls together cutting-edge protocols, written in a step-by-step, readily reproducible format certain to guide researchers to the desired results. Comprehensive and essential, Nanostructure Design: Methods and Protocols uses biological principles and vehicles on design... купить, скачать, интернет магазин As one of the fastest growing fields of research in the 21st century, nanotechnology is sure to have an enormous impact on many aspects of our lives. Nanostructure Design: Methods and Protocols serves as a major reference for theoretical and experimental considerations in the design of biological and bio-inspired building blocks, the physical characterization of the formed structures, and the development of their technical applications. The chapters contributed by leading experts are divided into two sections, the first of which covers experimental aspects of nanostructure design and the second delves into computational methods. As a volume of the highly successful Methods in Molecular Biology™ series, this collection pulls together cutting-edge protocols, written in a step-by-step, readily reproducible format certain to guide researchers to the desired results. Comprehensive and essential, Nanostructure Design: Methods and Protocols uses biological principles and vehicles on design......


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